首页|益肾中药复方防治大鼠继发性骨质疏松症的实验研究

益肾中药复方防治大鼠继发性骨质疏松症的实验研究

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目的:益肾中药复方用于实验性继发性骨质疏松症模型大鼠,观察其疗效,并对中药复方的机制做初步的探讨.方法:使用糖皮质激素肌肉注射制造继发性骨质疏松症动物模型,同时给予益肾中药复方治疗3 mo后,观察模型动物股骨骨密度(BMD)、血钙、血磷、血碱性磷酸酶(AKP)理化指标.结果:益肾中药复方治疗组大鼠股骨BMD高于模型组(P＜0.05),血钙、血磷、血AKP等均高于模型组(P＜0.05).结论:益肾中药复方能在一定程度上缓解由糖皮质激素诱发的骨质疏松症.
Treatment and protection of secondary osteoporosis in rats with"Kidney-Tonifying"Chinese herb compound
AIM: To observe the effect of "Kidney-Tonifying" Chinese herb compound on rats with secondary osteoporosis and to explore its mechanism. METHODS: By intramuscular injection of dexamethasone,the animal model of secondary osteoporosis was made and the animals were then given " Kidney-Tonifying" Chinese herb compound for 3 months. Bone mineral density( BMD) of femur and serum Ca,P and AKP were determined. RESULTS: The BMD of femur and the values of serum Ca,P and AKP in Chinese herb compound group were higher than those in control group ( P < 0.05). CONCLUSION: " Kidney-Tonifying" Chinese herb compound to some extent alleviates secondary osteoporosis.

osteoporosis/ETChinese herb compoundsrats

王育才、丁勇、范清宇、张殿忠、单乐群、尹艳

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第四军医大学唐都医院骨科,陕西,西安,710038

骨质疏松/病因学 中药复方 大鼠

2009

第四军医大学学报
第四军医大学

第四军医大学学报

CSTPCDCSCD北大核心
影响因子：0.599
ISSN：1000-2790
年,卷(期)：2009.30(11)
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