益肾中药复方防治大鼠继发性骨质疏松症的实验研究
Treatment and protection of secondary osteoporosis in rats with"Kidney-Tonifying"Chinese herb compound
王育才 1丁勇 1范清宇 1张殿忠 1单乐群 1尹艳1
作者信息
- 1. 第四军医大学唐都医院骨科,陕西,西安,710038
- 折叠
摘要
目的:益肾中药复方用于实验性继发性骨质疏松症模型大鼠,观察其疗效,并对中药复方的机制做初步的探讨.方法:使用糖皮质激素肌肉注射制造继发性骨质疏松症动物模型,同时给予益肾中药复方治疗3 mo后,观察模型动物股骨骨密度(BMD)、血钙、血磷、血碱性磷酸酶(AKP)理化指标.结果:益肾中药复方治疗组大鼠股骨BMD高于模型组(P＜0.05),血钙、血磷、血AKP等均高于模型组(P＜0.05).结论:益肾中药复方能在一定程度上缓解由糖皮质激素诱发的骨质疏松症.
Abstract
AIM: To observe the effect of "Kidney-Tonifying" Chinese herb compound on rats with secondary osteoporosis and to explore its mechanism. METHODS: By intramuscular injection of dexamethasone,the animal model of secondary osteoporosis was made and the animals were then given " Kidney-Tonifying" Chinese herb compound for 3 months. Bone mineral density( BMD) of femur and serum Ca,P and AKP were determined. RESULTS: The BMD of femur and the values of serum Ca,P and AKP in Chinese herb compound group were higher than those in control group ( P < 0.05). CONCLUSION: " Kidney-Tonifying" Chinese herb compound to some extent alleviates secondary osteoporosis.
关键词
骨质疏松/病因学/中药复方/大鼠Key words
osteoporosis/ET/Chinese herb compounds/rats引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据