维持性血液透析患者血清C反应蛋白与肺部感染的关系
Relation of serum C-reactive protein and pulmonary infection in patients with maintenance haemodialysis
雷定和 1尹友生1
作者信息
- 1. 桂林医学院附属医院肾内科,广西,桂林,541001
- 折叠
摘要
目的:探讨维持性血液透析(MHD)患者并肺部感染与C反应蛋白(CRP)的关系.方法:对96例MHD肺部感染者(A组,46例109例次感染)在治疗前后检测CRP水平,与无肺部感染者(B组,50例)对比并结合体温、白细胞计数、年龄、透析时间(T)、血红蛋白(Hb)、血浆白蛋白(Alb)、心胸比例(C/R)及透析充分性(Kt/V)等临床资料进行分析,20例健康体检者作为正常对照(C)组.结果:MHD患者血清CRP明显高于正常组;MHD患者并肺部感染时血清CRP显著高于无肺部感染,其灵敏性高于体温和白细胞计数(P＜0.01).血清CRP与年龄无相关,与T,C/R呈正相关(r=0.758,0.841,P均＜0.01),与Hb,Alb及Kt/V呈负相关(r=-0.159,P＜0.05;r=-0.190,P＜0.01;r=-0.168,P＜0.05).结论:MHD患者血清CRP水平明显高于正常对照组;严重贫血、营养不良及透析不充分是MHD患者诱发肺部感染的危险因素,从而诱导血CRP持续增高;动态监测CRP可作为MHD并肺部感染诊治的一个较敏感的指标.
Abstract
AIM: To explore the relation between serum C-reactive protein ( CPR ) and pulmonary infection in patients with maintenance haemodialysis(MHD). METHODS:CRP level was detected in 96 MHD patients with pulmonary infection before and after therapy and the results were compared with those in control group. Clinical references such as temperature,white blood count,age,dialysis time,hemoglubin,albumin,C/R and Kt/V were also analyzed. RESULTS: Serum CRP levels in MHD patients were higher than in control group and CRP levels in MHD patients with pneumonia were higher than those in not pulmonary. The sensitivity of CRP levels was better than that of temperature and white blood count(P<0.01). Serum CRP levels were not correlated to age,but were positively correlated to temperature and C/R (r = 0.758,0.841,P <0.01) and were negatively correlated to hemoglobin,albumin and Kt/V(r= -0.159,P<0.05;r = -0.190,P<0.01;r= -0.168,P<0.05). CONCLUSION:Serum CRP levels in MHD patients are obviously higher than those in control group. Severe anemia,malnutrition and dialysis inadequacy are risky factors inducing pneumonia and increasing the CRP levels. Dynamic monitoring of CRP can be used as a sensitive indicator in the diagnosis of MHD patients with pneumonia.
关键词
维持性血液透析/肺部感染/C反应蛋白Key words
maintenance haemodialysis/Pulmonary infection/C-reactive protein引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据