Effect of clopidogrel on blood concentration of hs-CRP and TNF-α and therapeutic effect for patients with non-ST elevation acute coronary syndrome
AIM: To observe the therapeutic effect of clopidogrel and its influence on blood concentration of hs-CRP and TNF-α in patients with non-ST elevation acute coronary syndrome. METHODS: Eighty patients with non-ST elevation acute coronary syndrome were randomized into 2 groups: Aspirin ( control group) and aspirin + clopidogrel(treatment group). Patients in the control group took 300 mg aspirin for the first time,followed by 100 mg aspirin per day,while patients in the treatment group took 300 mg aspirin and 300 mg clopidogrel for the first time,followed by 100 mg aspirin and 75 mg clopidogrel per day. The clinical symptoms and incidence of cardiac event of the 2 groups were observed. The concentrations of hs-CRP and TNF-α were detected in all the patients before as well as 7 and 30 d after the administration of medicine. RESULTS: Compare with those in control group,the clinical symptoms and major cardiac occurrence in treatment group decreased significantly ( P < 0. 05). Seven days after the administration of medicine,the concentrations of hs-CRP and TNF-α in both groups decreased significantly ( P < 0. 01). Thirty days after the administration of medicine,the concentrations further decreased and the concentrations of hs-CRP and TNF-α in treatment group were significantly lower compared with those in control group(P<0.05). CONCLUSION: Clopidogrel has some protective effect on the cardiovascular system and reduces the major cardiac occurrence in patients with non-ST elevation acute coronary syndrome. Clopidogrel also alleviates the inflammation of arteries and suppresses the progress of atherosclerosis by reducing the plasma level of hs-CRP and TNF-α,thus improving the prognosis of patients with acute coronary syndrome.
NETL
NSTL
万方数据
维普
