Effect of concurrent chemoradiation plus radiofrequency thermotherapy on locally advanced non-small cell lung cancer
AIM: To study the effect and the toleration of concurrent chemoradiation plus radiofrequency thermotherapy ( RT) on locally advanced unresectable non-small cell lung cancer. METHODS: One hundred and two patients between January 2003 and April 2007 were enrolled in this study. Patients with locally advanced unresectable non-small-cell lung cancer treated with concurrent chemoradiotherapy were randomized to 2 groups. Patients in control group (n =48) received Paclitaxel(60 mg/m2,I. V. on days 1,8,15,22,and 29) and cisplatin(25 mg/m2,I. V. on days 2,9,16,23,30) plus thoracic RT(total dose,60 Gy in 30 fractions of 2 Gy q. d. 5 d/week). Patients in treatment group (n =54) received the same treatment plus radiofrequency thermotherapy (HY-7000 type machine,one time every other day). All the pati ents received a two-cycle chemotherapy of TP regimen ( Paclitaxel 90 mg/m2,d1,8;cisplatin 25 mg/m2,d2 4,one cycle every 21 d). RESULTS: Eight (14. 8%) patients achieved complete response(CR),33(61. 1% ) partial response( PR),8( 14. 8% ) stable disease (SD ),and 5 (9. 3% ) progressive disease ( PD),with an overall response rate( RR) of 41 (75. 9% ) in treatment group,while 3(6.25%) CR,33(68.5%) PR,8(16.7%) SD and 4(8. 3%) PD,with an overall RR of 36(75%) in control group. No significant difference was found between the 2 groups (P>0.05). Grade 3 or 4 neutropenia,radiation esophagitis and pneumonitis were respectively found in 18(37.5% ),12(25.0% ) and 3(6. 3% ) patients in treatment group and 32(59. 3% ),24 (44.4%),11(20.4%) in control group,with significant difference between the 2 groups(P<0.05). CONCLUSION: Concurrent chemoradiation on locally advanced non-small cell lung cancer is well tolerated and radiofrequency thermotherapy significantly lessens the toxicities of concurrent chemoradiation and enhances the local control effectiveness.
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万方数据
维普
