摘要
目的:探讨非洛地平抗动脉粥样硬化的作用.方法:将30只日本大耳白兔分为对照组、动脉硬化组和治疗组3组,每组10只,对照组喂普通饲料,动脉硬化组和治疗组喂高脂饲料,治疗组同时给非洛地平2 mg/(kg·d)干预90d.实验前、45 d及90 d于耳缘动脉取血,检测血脂、一氧化氮(NO)及内皮素(ET),取动物的主动脉,并做HE染色.结果:90 d后治疗组兔动脉粥样硬化斑块的程度较动脉硬化组明显减轻,两组间血脂水平无显著性差异.治疗组与动脉硬化组相比,NO显著升高,ET显著降低.结论:非洛地平能抑制高脂血症所造成的兔动脉粥样硬化病变的形成,其作用并非通过降低血脂水平.可能与升高血清中一氧化氮,降低内皮素有关.
Abstract
AIM: To investigate the effects of felodipine on atherosclerosis. METHODS: Thirty Japanese albino rabbits were divided into 3 groups: control group,atherosclerosis group and experimental group. For 90 d,the animals in control group were fed with normal feeds,while those in atherosclerosis group and experimental group were fed with high fat feeds. The animals in experimental group were treated with felodipine for 90 d. Blood fat,nitric oxide (NO) and endothelins (ET) were tested before as well as 45 d and 90 d of the treatment. After the treatment,the animals were sacrificed for HE staining of the aorta. RESULTS: The atherosclerotic plaques were much lighter in experimental group compared with those in atherosclerosis group,but no significant difference was found in the blood fat level between the 2 groups. Plasma NO increased and ET decreased in experimental group compared with those in atherosclerosis group. CONCLUSION: Felodipine suppresses the formation of hyperlipemia-caused atherosclerotic plaque not by lowering the blood fat,which may relate with the increased plasma NO and decreased ET.
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维普
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