Effects of Ginsenoside Rg3 on GFAP and Vimentin expression in rat glioma
AIM: To investigate the effect of Ginsenoside Rg3 on GFAP and Vimentin expression in C6 glioma rat models and to explore the antiglioma mechanism, METHODS: C6 glioma rat models were established and the rats were divided into Ginsen-oside Rg3 group, placebo-treatment group and blank group. Ginsenoside Rg3 was administered 2 weeks after the intracranial injection of C6 cells in the rats. Four weeks after the administra-tion of Ginsenoside Rg3, the rats were sacrificed and the forma-tion of tumors was observed. GFAP and Vimentin expressions were detected by immunohistochemistry and the inter-group differ-ence was analyzed. RESULTS: GFAP and Vimentin-positive cells were observed in all the groups. Compared with those in con-trol group, the area density value (0.24±0.02) and the opticaldensity value (882.80±150.67) of GFAP expression increased obviously in Ginsenoside Rg3 group (P<0.01). Compared with those in control group, the area density value(0.10±0.01) and the optical density value(682.31±126.38) of Vimentin expres-sion decreased obviously in Ginsenoside Rg3 group(P<0.01). No statistical difference in GFAP and Vimentin expression levels was observed between placebo-treatment group and blank group. CONCLUSION: Ginsenoside Rg3 inhibits Vimentin expression and strengthens GFAP to achieve the anti-glioma effect.
NETL
NSTL
万方数据
维普
