Meta-analysis of prenatal screening for trisomy 21 using nuchal translucency measurement with serum markers
AIM: To evaluate the value of screening trisomy 21 by nuchal translucency(NT) measurement together with maternal serum biochemistry markers in first trimester. METHODS: A search was performed in Cochrane Library, Pub Med, OVID, Springer, China National Knowledge Infrastructure (CNKI) and Chinese Bio-medicine Database (CBM)to obtain relevant English and Chinese literature between January 1990 and August 2008. Criteria for inclusion were established based on the validity criteria for diagnostic research. The criteria-meeting data were collected and analyzed using Meta-DiSc 1.4. RESULTS: Fourteen re-search articles were included, with a total of 111 535 fetuses. These articles were analyzed for the value of screening of trisomy 21 using nuchal translucency (NT) measurement together with maternal serum biochemistry markers in first trimester. The pooled sensitivity and specificity were 0.89 (95% CI: 0.87-0.91) and 0.96 (95 % CI:0.96-0.96) respectively. The SROC curve was drawn and the area under the curve (AUC) was calcu-lated(AUC=0.971). CONCLUSION: The results suggest that the screening of trisomy 21 by elevated NT together with maternal serum biochemistry markers has a high sensitivity, specificity and accuracy and is suitable for prenatal screen.
NETL
NSTL
万方数据
维普
