Effects of ginsenoside Rb1 on behaviors and memory of lead-exposed mice
AIM: To explore the effects of ginsenoside Rb1 on the blood lead levels and behaviors of lesd-exposed mice. METHODS: Lead-exposed models of mice were established with lead acetate drinking water, and different doses of ginsenoside Rb1 (100, 50, 25 mg/kg) were fed. Morris water maze test was employed to evaluate the effects of ginsenoside Rb1 on the learning and memory functions of the lead-exposed mice. The blood lead content and the activity of superoxide dismutase(SOD) and nitric oxide synthase ( NOS ) were detected. RESULTS : Morris water maze test showed that the searching distance and the latent periods were extended in lead-exposure mice. The activity of SOD decreased while the activity of NOS increased compared with those in control group (P<0.05 or P<0.01). Ginsenoside Rb1 markedly shortened the searching distance and latent periods, decreased the blood lead content, promoted the activity of SOD, and lowered the activity of NOS (P<0.05 or P<0.01). CONCLUSION: The results suggest that ginsenoside Rb1 reduces the blood lead concentration and alleviates the learning and memory obstacles of lead-expesed mice by restoring the vitality of the antioxidant system.
lead poisoningginsenoside Rb1learning andmemorymice
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