Effects of methoxychlor on expression of ANGPT-1 on endometrium of female mice
AIM: To explore the effects of methoxychlor(MXC) on expression of ANGPT-1 on endometrium of female mice. METHODS: MXC was administrated to the adult female rats at doses of 0 (control), 50, 100 and 200 mg/(kg·d). Immuno-histochemical method and computerized image analysis technology were employed to detect the expression of ANGPT-1 on endometrium of MXC treated female mice. RESULTS: The expression level of ANGPT-1 in MXC groups was higher than that in control (P<0.01). Cyclic variations of endometrium were observed in 50, 100 and 200 mg/(kg·d) MXC groups and control group. Compared with that in control, the expression level of ANGPT-1 in 100 and 200 mg/(kg·d) MXC groups during proliferation phase was higher than that during secretory phase (P<0.01), but no significant difference was observed in the expression of ANGPT-1 in 50 mg/(kg·d) MXC group (P>0.05). CONCLUSION: The higher expression of ANGPT-1 in MXC-treated endometrium indicates that ANGPT-1 may play a pivotal role in the pathophysi-ology and development of diseases on endometrium.
NETL
NSTL
万方数据
维普
