Expression and clinical significance of NF-κB in gastric cancer and metastastic lymph nodes
AIM: To investigate the expression of nuclear facter-kappa B (NF-κB) in gastric cancer, pars-cancerous tissues and metastastie lymph nodes, and to analyze the relationship between NF-κB expression and tumor clinicopathological features and survival time and the relationship between lymph node metastasis and primary focus. METHODS: Immunohistochemical SP method was used to test the expressions of NF-κB on tissue microarray in 32 cases of gastric normal mucosa, 54 cases of pars-cancerous tissue, 41 cases of metastastic lymph nodes and 189 cases of gastric cancers. RESULTS: The positive rates of NF-κB were respectively 75%, 43% and 16% in gastric cancer, paracancer and normal mucosa, with significant difference between the 3 groups (P<0.05). In gastric cancer tissues, the expressions of NF-κB were related with histological differentiation, lymph node metastasis, depth of invasion, and Lanren type (P<0.05). The positive rates of NF-κB were significantly different in the 41 cases of gastric cancer and 41 cases of metastastic lymph nodes (P<0.05). In metastastic lymph nodes, the positive rates of NF-κB were higher. Kaplan-Meier survival analysis showed that the survival time of patients with negative NF-κB was higher than that of patients with positive NF-κB (P<0.05). COX regression analysis also showed that the expression of NF-κB was an independent prognostic factor of gastric cancer. CONCLUSION: The over-expression of NF-κB is involved in occurrence and development, histological differentiation, invasion, and metastasis of gastric cancers. Metastastic lymph nodes are heterogeneous compared with primary tumors. NF-κB can serve as a prognostic marker of gastric cancers.
NETL
NSTL
万方数据
维普
