Effects of burn oil of Chinese medicinal herbs on wound healing in scalded rats
AIM: To investigate the effects of burn oil of Chinese medicinal herbs on wound healing in scalded rats. METHODS: Three deep-Ⅱ-degree circular skin wounds with a diameter of 2.5 cm were prepared in the back of rats and were treated respectively with burn oil of Chinese medicinal herbs, zinc sulfadiasine cream and matrix ointment 1 time per day. The healing of the wounds was observed. The wound tissue samples were harvested at different times for histopathological examination and the content of hydroxyproline, type Ⅰ/Ⅱ collagen ratio and the fibrocyte eyele of the dermal wound were detected by ELISA assay and flow cytometry. RESULTS : The application of burn oil of Chinese medicinal herbs reduced the swelling and effusion and shortened the healing time of the wound with no wound infection. Pathological examination showed that bum oil of Chinese medicinal herbs alleviated topical inflammation. All layers of derma were well-differentiated. Effect of hydroxyproline and wound type Ⅰ/Ⅲ collagen ratio showed that bum oil of Chinese medicinal herbs promoted the collage hyperplasy of wounds and palliated scars. The observation of the fibrocyte cycle showed that burn oil of Chinese medicinal herbs promoted the dermal fibrocyte proliferation. CONCLUSION: Burn oil of Chinese medicinal herbs promotes the wound healing in scalded rats.
Chinese medicineoils, volatileburns/ZHhealingscalding
NETL
NSTL
万方数据
维普
