应用CT和肌电图评价A型肉毒毒素治疗良性咬肌肥大的疗效
Botulinum toxin type A for treatment of masseteric hypertrophy: An evaluation with computed tomography and electromyographic measurement
刘昕 1刘晓燕 2吴越 3杨本强 3邹明宇 3李子浩 3王金宝3
作者信息
- 1. 第二军医大学长海医院整形外科,上海,200433
- 2. 沈阳军区总医院整形外科,辽宁,沈阳,110016
- 3. 沈阳军区总医院放射诊断科,辽宁,沈阳,110016
- 折叠
摘要
目的:应用CT和肌电图评价A型肉毒毒素治疗后咬肌的厚度与电生理变化.方法:对入选的20例(40侧)咬肌肥大患者进行A型肉毒毒素肌肉注射治疗.咬肌肥大就医者每侧注射剂量为5万U/L.观察治疗前后不同时期就医者咬肌厚度变化情况、不良反应或并发症发生情况以及电生理的改变.结果:20例患者注射后CT与传统B超测最的咬肌厚度无明显差异.测量结果显示:不同时期的咬肌厚度均明显小于注射前,差异有统计学意义(P＜0.01).药物注射后4～12wk咬肌厚度减小最明显,12 wk后咬肌的力量与体积逐渐恢复,24 wk后肌力基本恢复正常,但咬肌体积的恢复各不相同.肌电变化显示:不同时期的运动单位电位幅度均较治疗前减小(P＜0.01).20例患者总体满意率为85%.结论:CT和肌电图对A型肉毒毒素治疗良性咬肌肥大的疗效可以进行很好的评价.
Abstract
AIM: To evaluate the effects of botulinum toxin type A on the thickness and electromyographic changes in the masseteric muscle using computed tomography and etectromyographic measurement. METHODS: Twenty patients (40 sides) with bilateral maaaetefic hypertrophy were treated with intramuscular injection of botulinum toxin type A, 50 000 U/L for each side. The thickness and electromyographic changes of masseter muscle and complications were recorded at different time points. RESULES: Computed tomography showed that the massetefic thickness of the 20 patients was significantly reduced post-injection compared with that pre-injection (P＜0.01). The maximum reduction was observed from 4th to 12th week after injection, and the strength and the volume of masseter gradually recovered 12 weeks after injection. Though the strength of masseter recovered to normal in most patients 24 weeks after injection, differences were observed in the recovery of masseteric volume. Electromyographic measurement showed that the extent of motor unit potential obviously reduced compared with that pre-injection (P＜0.01). Eighty-five percent of the 20 patients were generally satisfied with the therapeutic results. CONCLUSION: The therapeutic effect of botulinum toxin type A in the treatment of maaseteric hypertrophy can be evaluated by computed tomography and electromyographic measurement.
关键词
肉毒毒素/咬肌/CT/肌电图Key words
botulinum toxin type A/masseteric muscle/computed tomography/electromyographic measurement引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据