Smad 4在贲门及非贲门癌中的表达及其与生存的关系
Relationship between Smad 4 protein expression and patient survival in cardia and noncardia gastric cancer
李强 1周永宁 1张志镒 2姬瑞 1路红 1刘伟3
作者信息
- 1. 兰州大学第一医院消化内科,甘肃,兰州,730000
- 2. 兰州大学甘肃省武威肿瘤医院,甘肃,武威,733000
- 3. 兰州大学基础医学院病理研究所,甘肃,兰州,730000
- 折叠
摘要
目的:研究Smad4在胃贲门和非贲门癌中的表达状况,分析其表达与临床病理特征及生存之间的关系,探讨贲门癌的发病机制.方法:应用免疫组化及组织芯片技术,对78例贲门癌、113例非贲门癌组织中的Smad 4蛋白表达情况进行分析.结果:贲门及非贲门癌中Smad 4蛋白的阳性表达率分别为67.9%和66.4%.在贲门癌中Smad4蛋白表达与患者年龄及分化程度有关(P＜0.05);在非贲门癌中Smad 4的表达与各临床病理特征均无相关性(均P＞0.05).生存分析表明,Smad 4表达仅与非贲门癌患者的预后有关(P=0.010).结论:在胃贲门和非贲门癌中Smad 4的表达对患者临床病理特征的影响不尽相同.Smad 4蛋白表达对非贲门癌患者的预后有一定的作用.贲门胃癌不仅在分子水平上同非贲门癌存在差异,在生存预后方面亦存在不同.
Abstract
AIM: To evaluate the expression pattem of Smad 4 protein in cardia and noncardia gastric cancers and to determine the relationship between Smad 4 and tumor clinicopathological features as well as the survival time. METHODS: Tissue microarray was used to determine Smad 4 protein expression by immunohistochemistry S-P in 78 cardia and 113 noncardia cancer cases. RESULTS : The positive expression rates of Smad 4 protein in the tissues of cardia and noncardia gastric carcinoma were 67.9% and 66.4% respectively. Smad 4 expression was found to be statistically associated with the age and tumor differentiation status(P＜ 0.05) in cardia gastric carcinoma, while no close relation was found between Smad 4 expression and the clinicopathological features in noncardia carcinoma(P＞0.05). Smad 4 positive expression was associated with favorable survival time only in noncardia gastric cancer(P＜0.05). CONCLUSION: There exist differences between the expression of Smad 4 and the clinicopathological features in cardia and noncardia gastric cancers. The expression pattern of Smad 4 protein affects survival time in noncardia gastric carcinoma.
关键词
贲门癌/非贲门癌/Smad4/临床病理特征/生存期Key words
cardia cancer/noncardia cancer/Smad 4/clinicopathology/survival time引用本文复制引用
基金项目
甘肃省科学事业费资助项目(QS061-C33-18)
出版年
2009
NETL
NSTL
万方数据