Research on expressions of P16 and P53 proteins and PCNA in elderly patients with gastric cancer
AIM: To study the expressions of P16 and P53 proteins and proliferating cell nuclear antigen (PCNA) in the occurrence and development in elderly patients with gastric cancer. METHODS: P16 and P53 proteins as well as PCNA expressions were detected in 57 specimens of gastric cancer and pericarcinoma tissues, and 19 samples of normal gastric tissues by immunohistochemistry. The data were analyzed together with clinical manifestations. RESULTS: The positive rate of P16 protein expression was 21% (12/57) in gastric cancer samples, significantly lower than that in both pericarcinoma tissues 60% (34/57) and normal gastric tissues 89% (17/19, P ＜ 0.05). The positive rates of P53 protein and PCNA expression were 81% (46/57) and 93% (53/ 57) in gastric cancer samples, significantly higher than those in pericarcinoma tissues (42%, 61%) and normal gastric tissues (0%, P ＜ 0.05). The positive expressions of the P16 and P53 proteins and PCNA were correlated with the histological types and degrees of differentiation of gastric cancer and the depth of invasion and lymph node metastasis (P ＜ 0.05), but were not correlated with the age, sex, tumor size and sites (P ＞ 0.05). CONCLUSION: Abnormal expressions of P16 and P53 proteins, and PCNA are closely correlated to the occurrence, development, malignancy degrees, lymph node metastasis and prognosis of gastric cancer. The detection of P16, P53 and PCNA is of important clinical significance for gastric cancer therapy.
NETL
NSTL
万方数据
维普
