Relationship between expression of Rac1 in gastric carcinoma and its biological behavior and patient survival
AIM: To evaluate the expression pattern of Rac1 in gastric carcinoma and to analyze its relationship with tumor clinicopathological features and patient survival. METHODS: Issue microarray and immunohistochemical staining of Rac1 were performed from paraffin specimens(SP) of 189 gastric carcinomas, 54 paracancer, 59 lymph nodes and 30 healthy controls. RESULTS: Expression of Rac1 was observed in 72.0% of the gastric carcinoma, 55.6% of the paracancer and 13.3% of the healthy controls (P ＜ 0.01). Expression of Racl was significantly correlated with lymph node metastasis, tumor differentiation status, Lauren classification and invasive depth (respectively P ＜ 0.05). The rate of Racl expression was higher in the primary gastric carcinomas (82.5%) compared with that in the lymph node metastasis(60.0%) (P ＜ 0.05). Positive expression of Rac1 implicated a survival danger (P ＜ 0.05). CONCLUSION: Expression of Rac1 may be an early molecular event in the tumor genesis and is closely related to the tumor clinicopathological features and the patient survival. Expression of Rac1 is involved in the genesis and development of gastric carcinoma and it can be used as a prognostic marker.
stomach neoplasmsRac1immunohistochemistrypathology, clinicalsurvival time
NETL
NSTL
万方数据
维普
