Expression of hK11 in breast cancer and its association with clinical pathological feature
AIM:To investigate the expression of hK11 in primary breast cancer and to evaluate its clinical significance in clinicopathological status of patients with primary breast cancer. METHODS: Eighty-six patients with primary breast cancer were examined for hK11 protein expression by immunohistochemistry. RESULTS: The positive rale of hK11 was respectively 76% (65/86) in the cytoplasm of tumor cells and 19% (16/86) in the adjacent non-malignant tissues, with a significant difference (P ＜ 0.01). The expression of hK11 was positively correlated with the TNM stage of the breast cancer (P ＜ 0.01), the percentage of involved lymph nodes (P ＜ 0.05) and HER-2 (P ＜ 0.05). No significant correlation was found between the expression of hK11 and the age, the tumor size, ER, PR and menopause. CONCLUSION: The expression of hK11 may play an important role in the pathogenesis of primary breast cancer.
breast neoplasmspathology, clinicalhK11immunohistochemistry
NETL
NSTL
万方数据
维普
