原发性肾病综合征与血清超敏C反应蛋白相关分析
Correlation between ultrasensitive Creactive protein and primary nephrotic syndrome
杨世峰 1尹爱萍 1谭峰 1杨亚丽1
作者信息
- 1. 西安交通大学医学院第一附属医院肾脏内科,陕西,西安,710061
- 折叠
摘要
目的:探讨C反应蛋白(CRP)与原发性肾病综合征(PNS)的关系.方法:采用免疫散射比浊法测定超敏C反应蛋白(hsCRP),观察76例PNS患者和健康对照组的血清hsCRP以及其它指标的水平.结果:PNS患者血清hsCRP水平较对照组明显升高.Pearson相关分析显示hsCRP与质量指数(BMI)、收缩压(SBP)和舒张压(DBP)成正相关(P<0.05),逐步线性回归分析显示BMI是影响hsCRP的主要因素.结论:PNS患者体内存在以血清hsCRP升高为代表的微炎症反应,并且与患者的BMI,SBP和DBP明显相关,但是与蛋白尿、低白蛋白血症以及高脂血症等PNS的并发症无相关性.
Abstract
AIM: To investigate the correlation between C-reactive protein (CRP) and primary nephrotic syndrome (PNS). METHODS: Seventy-six patients with PNS and 40 healthy subjects were included in the study. The serum high sensitivity C-reactive protein (hsCRP) and other related indexes were measured and analyzed. RESULTS:The level of hsCRP in patients with PNS was significantly higher than that in control group. Pearson correlation analysis indicated that the hsCRP level was positively correlated with body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP) (P ＜ 0.05). Stepwise linear regression showed a linear correlation between BMI and hsCRP. CONCLUSION: Microinflammation featured by increased hsCRP level exists in patients with PNS, and the hsCRP level is associated with BMI and blood pressure but not with complications of PNS, such as proteinuria, hypoproteinemia and hyperlipoidemia.
关键词
肾病综合征/C反应蛋白质/人体质量指数/血压Key words
nephrotic syndrome/C-reactive protein/body mass index/blood pressure引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据