Association of - 759C/T polymorphism of 5-HT2C receptor gene with type 2 diabetes in Gansu Dongxiang nationality
AIM: To study the association of -759C/T polymorphism of 5-HT2C receptor (HTR2C) gene with type 2 diabetes and obesity in Gansu Dongxiang nationality. METHODS: HTR2C gene - 759C/T polymorphism was detected by PCR-ligase detection reaction (PCR-LDR) technique in 100 type 2 diabetics and 126 normal control subjects. The clinical parameters and serum markers were measured. RESULTS: The frequency of CC and CT genotypes in female diabetics and normal control subjects were 80.6% and 19.4%, and 61% and 39% respectively. The frequency of CT genotype was significantly lower in the female diabetics than that in the normal control subjects (P = 0.047) and the allele frequencies showed no statistical difference between the two groups (P = 0.073). The frequency of C and T hemizygote showed no statistical difference between male diabetics and normal control subjects (P = 0.727). The genotype and allele frequencies of - 759C/T were not significantly different between female obese group and non-obese group (P ＞ 0.05). The frequency of C and T hemizygote showed no significant difference between male obese group and non-obese group. CONCLUSION: The HTR2C gene -759C/T polymorphism is associated with type 2 diabetes in female Dongxiang nationality. -759C→T may be a protective factor for the development of T2DM.
receptor, serotonin, 5-HT2Cdiabetes mellitus, type 2polymorphism, genetic
NETL
NSTL
万方数据
维普
