Effect of cadmium and tea polyphenols on action potential in rat myocardial cells
AIM: To investigate the effect of CdCl2 and tea phlyphenols(TP) on the action potential in rat myocardial cells. METHODS: Action potentials were recorded using standard microelectrode technique. RESULTS; CdCl2 of different concentrations decreased the amplitude of action potential(APA) and the maximum rate of depolarization(Vmax), and shortened the action potential duration of repolarization (APD). CdCl2/L at 0.005 mmol decreased APA from 74.9 ± 4.8 to 66.5 ± 6.7 and Vmax from 15.3 ± 2.3 to 16.1 ± 2.5, CdCl2/L at 0.01 mmol decreased APA to 50.3 ± 2.4 and Vmax to 9.3 ± 0.9 and CdCl2/L at 0.015 mmol decreased APA to 46.2 ± 3.1 and Vmax to 3.7 ± 0.6. TP decreased the effects of CdCl2 on the action potential in rat myocardium. CONCLUSION: CdCl2 inhibits the action in rat myocardial cells and TP decreases the effects of CdCl2 on the action potential in rat myocardium.
NETL
NSTL
万方数据
维普
