白血病患者杀伤细胞免疫球蛋白样受体(KIR)基因多态性分析
Analysis of killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia
张艳 1刘晟 1叶世辉 1刘孟黎 1沈春梅 1齐君 1王波2
作者信息
- 1. 陕西省血液中心血型研究室,陕西西安710061
- 2. 第四军医大学军事预防医学系流行病学教研室,陕西西安710033
- 折叠
摘要
:激活型KIR2DS4可能与慢性粒细胞白血病发病有一定的关联.
Abstract
AIM: To investigate the association of killer cell immunoglobulin-like receptors (KIR) gene polymorphisms with leukemia. METHODS: Two hundred and sixty-three patients and two hundred thirty-nine randomly selected controls were genotyped for KIR genes by PCR-SSP. RESULTS: The genotypic frequencies of KIR2DL4, 3DL2, 3DL3 and 3DP1 were 1.000 in all the patients and controls under study. The genotypes of KIR2DL1, 2DL3, 3DL1 and 2DP1 were most prevalent genotypes while the frequency of genotype 2DL5B was very low in all the patients and controls under study. The frequency of KIR2DS4 was much higher in patients with chronic granulocytic leukemia(CML) than that in controls(P ＜ 0.01). CONCLUSION: The activating genotype KIR2DS4 may be associated with the susceptibility of CML.
关键词
白血病/杀伤细胞免疫球蛋白样受体/基因多态性Key words
leukemia/killer cell immunoglobulin-like receptors/gene polymorphism引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据