Analysis of killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia
AIM: To investigate the association of killer cell immunoglobulin-like receptors (KIR) gene polymorphisms with leukemia. METHODS: Two hundred and sixty-three patients and two hundred thirty-nine randomly selected controls were genotyped for KIR genes by PCR-SSP. RESULTS: The genotypic frequencies of KIR2DL4, 3DL2, 3DL3 and 3DP1 were 1.000 in all the patients and controls under study. The genotypes of KIR2DL1, 2DL3, 3DL1 and 2DP1 were most prevalent genotypes while the frequency of genotype 2DL5B was very low in all the patients and controls under study. The frequency of KIR2DS4 was much higher in patients with chronic granulocytic leukemia(CML) than that in controls(P ＜ 0.01). CONCLUSION: The activating genotype KIR2DS4 may be associated with the susceptibility of CML.
NETL
NSTL
万方数据
维普
