Genetic association of estrogen receptor-alpha polymorphisms with chronic hepa-titis B virus infection in Gansu Province
AIM: To investigate the association between patients with HBV in Gansu Province and the polymorphisms of estrogen receptor(ER) alpha gene at the position-29. METHODS: Polymorphisms of ERα-29 were analyzed in 104 chronic hepatitis B patients, 68 patients with HBV-induced cirrhosis and 80 healthy controls by polymerase chain react restriction fragment length Polymorphism(PCR-RFLP) technique. RESULTS: The frequencies of TT genotype and T allele of ERα-29 in patients with chronic hepatitis B and HBV-induced cirrhosis were higher than those in controls, while the frequencies of TC and CC genotype and C allele of ERα-29 in patients with chronic hepatitis B and HBV-induced cirrhosis were lower than those in controls (P ＜ 0.01). The risk of chronic hepatitis B and HBV-induced cirrhosis occurrence in carriers with T allele was 2.58 and 3.11 folds respectively than that in controls. There was no significant difference in frequencies of allele and genotype of ERα-29 between chronic hepatitis B group and HBV-induced cirrhosis group. The frequency of ERα-29 genotypes TT and T allele in patients with HBeAg-negative was markedly higher than that in the HBeAg-positive group (P ＜ 0.05). ERα-29 TT genotype had an increased tendency in the decompensated hepatocirrhosis group, but there was no statistical significance between compensatory hepatic cirrhosis group and decompensated hepatocirrhosis group. CONCLUSION: The polymorphisms in the estrogen receptor alpha gene at the position-29 are associated with HBV infection.
estrogen receptorgene polymorphismhepatitis Bliver cirrhosis
NETL
NSTL
万方数据
维普
