Expression and significance of β-cate-nin and hPTTG1 in colorectal cancer
AIM: To explore the expression and prognostic significance of β-catenin and hPTTG1 in colorectal carcinoma tissues. METHODS: The expressions of β-catenin and hPTTG1 in 79 colorectal carcinoma tissues and 20 normal colorectal tissues around the foci were detected by SP immunohistochemistry. The expressions of β-catenin and hPTTG1 and their correlations to the clinic pathological features and the prognosis of colorectal carcinoma were analyzed. RESULTS: β-catenin was expressed negatively in all the 20 normal colorectal tissues while the positive rate of β-catenin in colorectal carcinoma was 77.2%, with statistically significant difference between the 2 groups (P ＜ 0.01). The abnormal expression of β-catenin was correlated with localizations of tumor, differentiation grades, lymph node metastases, Dukes' stages, and ascites(χ2 = 5.975, 6.041,4.347, 7.364, 5.513, P ＜ 0.05). hPTTG1 was expressed negatively in all the normal colorectal tissues while the positive rate of hPTTG1 in colorectal carcinoma was 65.8%, with statistically significant difference (P ＜ 0.01). The positive expression of hPTTG1 was related to tumor sizes, differentiation grades, lymph node metastases, Dukes' stages, peritoneal dissemination and ascites(χ2 = 6.393, 6.446, 24.017, 5.788, 9.614, 13.067, P ＜ 0.05). Multivariate analysis showed that hPTTG1, lymph node metastases, Dukes' stages, ascites, and tumor sizes were independent prognostic indicators (RR=2.916, 3.546, 2.703, 2.217, 1.952, P ＜ 0.05), CONCLUSION: The deregulation of β-catenin and hPTTG1 expressions may correlate to the occurrence, development and metastasis of colorectal carcinoma. hPTTG1 may be a novel prognostic marker of colorectal carcinoma.
NETL
NSTL
万方数据
维普
