Expression of Fas-FasL in ITP patients and correlative study on Chinese medical syndromes
AIM: To explore the expression of apoptosis associated proteins Fas/FasL of T lymphocytes in patients with idiopathic thrombocytopenic purpura(ITP) and to study its correlation with Chinese medical syndromes. METHODS: Eighty cases of ITP patients were divided into 4 groups based on Chinese medical differentiation-classification and 20 healthy volunteers were employed as normal control group. The expression rate of membrane Fas/FasL of T lymphocytes was determined by flow cytometry. RESULTS: Compared with that in healthy control group, the expression rate of Fas/FasL on CD4+ and CD8+ T cells membrane significantly increased in groups of blood-heat (Xuere-wangxing) and ecchymosis-stay(Yuxue-zuluo) (P ＜ 0.05). Compared with that before treatment, the expression rate of Fas/FasL on CD4+ and CD8+ T cells membrane decreased in group of blood-heat after treatment, while no statistical significance was observed in group of ecchymosis-stay. Compared with that in healthy control group, the expression rate of Fas/FasL on CD4+ and CDS+ T cells membrane in groups of yin-deficiency fire-energy and air-deficiency slightly increased, with no statistical significance. CONCLUSION: Apoptotic speed of T lymphocytes in ITP patients of blood-heat (Xuere-wangxing) and ecchymosis-stay (Yuxue-zuluo) accelerates. Hormone therapy may interfere Fas/ FasL signal transduction pathway of apoptosis. Chinese medical syndromes of ITP patients is correlated with Fas/Fasl on CD4+ and CD8+ T cells membrane.
NETL
NSTL
万方数据
维普
