特发性血小板减少性紫癜Fas-FasL表达与中医辨证分型的关系
Expression of Fas-FasL in ITP patients and correlative study on Chinese medical syndromes
封蔚莹 1钮易蓓 2钟永根 1罗洪强1
作者信息
- 1. 绍兴市人民医院血液科,浙江绍兴312000
- 2. 绍兴市人民医院中西医结合科,浙江绍兴312000
- 折叠
摘要
阻络组略有上升,但差异无显著性.CD4+及CD8+外周血T亚群表面凋亡调控因子Fas/Fasl表达率ITP阴虚火旺组、气虚不摄组治疗前与对照组相比较有所增加,治疗后略有上升,但差异均无显著性.结论:ITP患者中医辨证分型与Fas/FasL表达存在相关性.ITP患者较高的T亚群表面凋亡调控因子Fas,Fasl值,提示好的预后.
Abstract
AIM: To explore the expression of apoptosis associated proteins Fas/FasL of T lymphocytes in patients with idiopathic thrombocytopenic purpura(ITP) and to study its correlation with Chinese medical syndromes. METHODS: Eighty cases of ITP patients were divided into 4 groups based on Chinese medical differentiation-classification and 20 healthy volunteers were employed as normal control group. The expression rate of membrane Fas/FasL of T lymphocytes was determined by flow cytometry. RESULTS: Compared with that in healthy control group, the expression rate of Fas/FasL on CD4+ and CD8+ T cells membrane significantly increased in groups of blood-heat (Xuere-wangxing) and ecchymosis-stay(Yuxue-zuluo) (P ＜ 0.05). Compared with that before treatment, the expression rate of Fas/FasL on CD4+ and CD8+ T cells membrane decreased in group of blood-heat after treatment, while no statistical significance was observed in group of ecchymosis-stay. Compared with that in healthy control group, the expression rate of Fas/FasL on CD4+ and CDS+ T cells membrane in groups of yin-deficiency fire-energy and air-deficiency slightly increased, with no statistical significance. CONCLUSION: Apoptotic speed of T lymphocytes in ITP patients of blood-heat (Xuere-wangxing) and ecchymosis-stay (Yuxue-zuluo) accelerates. Hormone therapy may interfere Fas/ FasL signal transduction pathway of apoptosis. Chinese medical syndromes of ITP patients is correlated with Fas/Fasl on CD4+ and CD8+ T cells membrane.
关键词
Fas表达/FasL表达/Caspase-3/紫癜/血小板减少性/特发性/辨证分型Key words
Fas/FasL/casepase-3/purpura, thrombocytopenic/syndrome differ classification引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据