Effect of berberine on membrane fluidity and membrane protein fluorescence of rabbit red-blood cells
AIM: To investigate the effects of berberine on the membrane fluidity and membrane protein fluorescence of red-blood cell membrane. METHODS: With rabbit red-blood cell membrane as the experimental material and DPH (1,6-diphenyl-1, 3, 5-hexatriene)as the fluorescence probe, the effect of berberine on the cell membrane fluidity and membrane protein fluorescence was examined by fluorescence spectrum analytical method. RESULTS: The P value of rabbit red-blood cell membrane fluidity was decreased and the fluorescence of rabbit red-blood cell membrane protein was quenched by berberine dose-dependently. CONCLUSION: Berberine effectively enhances the membrane fluidity, suggesting that the increasing membrane fluidity is related to the multiple cardiovascular pharmacological activities. The effect of berberine on the membrane protein may result from the changes of membrane fluidity.
berberine/pharmacologyerythrocyte membranemembrane proteinsphysiological effects of drugsantimicrobial activity
NETL
NSTL
万方数据
维普
