Effect of glutamine precondition on platelet aggregation and activation functions in rabbits with spinal cord ischemia/reperfusion injury
AIM: To explore the effect of glutamine precondition on platelet aggregation and activation functions in rats with spinal cord ischemia/reperfusion injury (SCIRI). METHODS: SCIRI models were established with Zivin method in rabbits. The platelet aggregation Test(PAgT) and the plasma GMP-140 were observed dynamically. RESULTS: PAgT and GMP-140 concentration in the IR group started to increase at 45 min after ischemia and continued to increased until 6 h after reperfusion, and then decreased to the level before ischemia at 12 h after reperfusion, Glutamine precondition delayed the peak of platelet activation. CONCLUSION: Enhanced PAgT and excessively activated blood platelet function may be involved in the pathological process of SCIRI, which can be activated by glutamine preconditioning.
NETL
NSTL
万方数据
维普
