Clinical observation of colloidal chromium phosphate combined with cisplatin in treatment of malignant pleural effusion
AIM: To investigate the clinical efficacy and the side effects of intrapleural injection with colloidal chromium phosphate (32P) plus cisplatin for treating malignant pleural effusion. METHODS: Forty-six patients with malignant pleural effusion were randomly divided into the therapeutic group (n = 25) and the control group (n = 21). Cisplatin and 32P were injected into pleural cavity in therapeutic group, and only 32P was given in control group. RESULTS: Twenty-four patients were evaluated in therapeutic group with clinical response, including 45.8%(11/24), PR 37.5% (9/24), NC 16.7% (4/24). The totle effective rate is 83.3%. There were no recurrence of 5 CR patients and 2 PR patients after 2 months follow-up. The clinical response in control group were CR 4.8% (1 case) , PR 33.3% (7 cases) , NC 61.9% (13 cases). The total effective rate in therapeutic group was higher than those in control group (χ2 = 9.75, P ＜ 0.01). The main side effects among therapeutic course were mild systemic reaction and mild bone marrow suppression. CONCLUSION: Intrapleural injection with 32P combined with cisplatin seem to be an effective method for treating malignant pleural effusion without serious complication.
NETL
NSTL
万方数据
维普
