首页|伴远处转移胰腺癌患者化疗风险预测模型研究

伴远处转移胰腺癌患者化疗风险预测模型研究

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目的:对伴远处转移胰腺癌患者化疗风险预测模型进行研究. 方法:回顾性分析87例出现远处转移的胰腺癌患者应用5-Fu,顺铂、吉西他滨等化疗后的预后. 结果:全组中位生存时间为3.8 mo;3,6,12 mo的生存率分别为58%,26%和3%.Cox累计风险比例模型分析提示:腹水、血清胆碱酯酶水平(ChE)<110 U/L和年龄≥65岁都是独立的不良预后因素. 结论:伴远处转移胰腺癌患者化疗风险预测模型:相对死亡风险(RRD)=exp(腹水×1.213+ChE×1.065+年龄×0.651).
Predictive model of systemic chemotherapy risks in pancreatic cancer patients with distant metastasis
AIM: To establish the predictive model of systemic chemotherapy risks in pancreatic cancer patients with distant metastasis. METHODS: Eighty-seven pancreatic cancer patients with distant metastasis treated with systemic chemotherapy using 5-fluorouracil, cisplatin or gemcitabine were analyzed retrospectively to investigate the prognostic factors. RESULTS: The overall median survival time of all the patients under study was 3.8 months, and the survival rates of 3, 6 and 12 months were 58%, 26% and 3% respectively. Cox proportional hazards model showed that independent poor prognostic factors were the presence of ascites, serum ChE level ＜ 110 U/L, and age ≥ 65. CONCLUSION: The predictive model of systemic chemotherapy risks in pancreatic cancer patients with distant metastasis is: the relative risk of death (RRD) = exp (presence of ascites × 1.213 + serum ChE level × 1.065 + age ≥ 65 × 0.651).

pancreatic neoplasmschemotherapy riskforecastingmodels, statistical

常东民、马刚、张勇、王作仁、姬生威

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西安交通大学第一附属医院,肿瘤外科,陕西,西安,710061

西安交通大学第一附属医院,肝胆外科,陕西,西安,710061

胰腺肿瘤 化疗风险 预测 模型 统计学

陕西省科技攻关项目

2008K09-03

2009

第四军医大学学报
第四军医大学

第四军医大学学报

CSTPCDCSCD北大核心
影响因子：0.599
ISSN：1000-2790
年,卷(期)：2009.30(18)
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