Using comparative genomics to analyze the function of human NDRG2
AIM:To predict the function of NDRG2 and provide some clues for further experimental study. METHODS: Comparative genomics is used to analyze the transcriptional regulation of ndrg2, search homogeneous proteins and understand the structure of NDRG2. RESULTS: Human ndrg2 has two transcriptional start sites, the long transcriptional start site is similar to the transcriptional start site in bos taurus and the short transcriptional start site is similar to the transcriptional start site in mouse. Homogeneous proteins are found in different species and MESK2 is the homogeneous proteins of NDRG2 in Drosophila melanogaster. Many structure neighborhoods of NDRG2 are found. The key amino acids of hydrolase have been changed in NDRG2. CONCLUSION: ndrg2 may have two different regulation styles in human species. There is a mini promoter between those two transcriptional start sites. The homogeneous proteins of NDRG2 exist in Metazoans, and are not found in Protista. These homogeneous proteins involve cell differentiation. NDRG2 belongs to a/β hydrolase superfamily structurally, but it may not have the activity of hydrolase for loss of key amino acids.
NETL
NSTL
万方数据
维普
