Design, synthesis of salidroside analogues and their antifatigue effect
AIM: In order to optimize the structure of salidroside, some of its analogues were synthesized and their antifatigue activities were also investigated. METHODS: Firstly, Tetra-O-α-acetyl-D-glucopyranosyl bromide was prepared, which reacted with benzylalcohol, benzene alcohol and phenylpropanol respectively afforded corresponding glycosides. Then, the target compounds were obtained by deacetyl of these glycosides. Secondly, the antifatigue properties of the analogues were studied by examining survival time in mice with exhausting swimming. RESULTS: Eight new salidroside analogues were synthesized, which structures were confirmed by 1H-NMR. The experiments showed that Salidroside and benzyl galactoside can significantly lengthen the burden swimming time, and there is no apparent difference on antifatigue activities between these 2 groups. Phenylprogyl glycoside, phenethyl glycoside and benzyl glucoside can also lengthen the burden swimming time, however there is no statistical significance. CONCLUSION: The synthetic method of the analogues was reliable. All the changes of the structure of salidroside, including length of carbochain, hydroxyl group and the type of saccharide group, have influence on antifatigue activity.
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