Pro-oxidative effect of epigallocatechin 3-gallate on human erythrocyte membranes
AIM: To explore the pro-oxidative effect of epigallocatechin-3-gallate (EGCG) on erythrocyte membranes and the molecular mechanism of action. METHODS: Human erythrocytes or their membranes were treated with EGCG and p-benzoquinone. Alterations in cellular morphology, glutathione levels and SDS-PAGE patterns of membranes were recorded and compared. RESULTS: The results showed that EGCG induced erythrocyte membrane damages, including changing cellular morphology, inducing sulfhydryl consumption and membrane protein aggregation. The results of p-benzoquinone acting on erythrocyte membranes shared same manner as that of EGCG. CONCLUSION: EGCG played a pro-oxidative effect on erythrocyte membranes through a pathway involved in quinone-like intermediates.
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维普
