Establishment of a new animal model of UHMWPE wear debris induced aseptic loosening
AIM:To establish a new animal model of UHMWPE wear debris induced aseptic loosening. METHODS: Twelve female new England rabbits were divided into 2 groups randomly, HA coating implants were inserted into the left tibia cavities and 25 μg UHMWPE particles were laid on the HA surface of the experimental group prior to surgery. After 12 weeks' observation, histomorphometry, biomechanics test and SEM were performed to evaluate the new aseptic loosening model. RESULTS: Compared with those in control group, the cortical bone thickness, biomechanical fixation stability, bone-implant contact, peri-implant bone volume fraction, bone mineralization and peri-implant bone density all decreased in experimental group. CONCLUSION: We have established a new rabbit model of UHMWPE wear debris induced aseptic loosening.
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万方数据
维普
