UHMWPE颗粒导致假体无菌性松动模型的建立
Establishment of a new animal model of UHMWPE wear debris induced aseptic loosening
牛舜 1孔令擘 1杨重飞 1朱庆生1
作者信息
- 1. 第四军医大学西京医院骨科,陕西,西安,710033
- 折叠
摘要
目的:建立超高分子质量聚乙烯(UHMWPE)颗粒导致的人工关节无菌性松动动物模型.方法:将12只平均体质量3 kg的雌性新西兰大白兔随机平分为实验组和对照组,两组均向左侧胫骨髓腔竖直植入羟基磷灰石(HA)涂层假体.实验组于植入前向假体表面均匀涂抹25μg UHMWPE颗粒,对照组不做处理.术后12 wk回收标本行骨组织形态学、生物力学以及影像学测量,评估新模型效果.结果:同对照组相比,实验组的骨皮质厚度、生物力学固定强度、骨-假体接触率、假体周围骨体积分数、骨矿化水平和假体周围骨密度均有所下降.结论:成功建立了假体表面涂抹UHMWPE颗粒诱导新西兰大白兔人工关节假体无菌性松动的动物模型.
Abstract
AIM:To establish a new animal model of UHMWPE wear debris induced aseptic loosening. METHODS: Twelve female new England rabbits were divided into 2 groups randomly, HA coating implants were inserted into the left tibia cavities and 25 μg UHMWPE particles were laid on the HA surface of the experimental group prior to surgery. After 12 weeks' observation, histomorphometry, biomechanics test and SEM were performed to evaluate the new aseptic loosening model. RESULTS: Compared with those in control group, the cortical bone thickness, biomechanical fixation stability, bone-implant contact, peri-implant bone volume fraction, bone mineralization and peri-implant bone density all decreased in experimental group. CONCLUSION: We have established a new rabbit model of UHMWPE wear debris induced aseptic loosening.
关键词
无菌性松动/动物模型/骨溶解/人工关节Key words
aseptic ioosening/animal model/osteolysis/artificial joint引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据