Expression and effect of CTGF, PDGF, VEGF on gluteal muscle contracture
AIM: To explore expression and effect of CTGF, PDGF and VEGF on gluteal muscle contracture (GMC). METHODS: Harvest contraction band and adjacent muscle from GMC patients and explore the expression of CTGF, PDGF and VEGF using immunohistochemistry, reverse transcription and polymerase chain reaction (RT-PCR) and Western Bolt analysis. RESULTS:CTGF, PDGF and VEGF was intensely expressed in fibroblast cells and vascular endothelial cells. The expression of those increased 3.5-fold, 5.8-fold and 2.9-fold at mRNA level, respectively(P ＜ 0.05). Same changes were found in protein level, they increased 3.9-fold, 6.2-fold and 2.9-fold, respectively (P ＜ 0.05). CONCLUSION: Increased expression of CTGF, PDGF and VEGF may initiate and propagate the fibrotic cascade in the gluteal muscles of GMC patients.
NETL
NSTL
万方数据
维普
