Effects of transcatheter arterial chemo-embolization on growth and metastasis of rabbit VX2 hepatic tumor
AIM: To evaluate the efficency, as well as effects of transcatheter arterial chemoembolization (TACE) on growth and metastasis of rabbit VX2 hepatic tumor. METHODS: 45 rabbits with implanted hepatic VX2 tumor were randomly divided into 3 groups with 15 rabbits in each group. Control group: 0.5 mL saline was perfused via hepatic artery in VX2 tumor bearing rabbit models; Transcatheter hepatic arterial infusion (TAI) group: 5 mg adriamycin was perfused via hepatic artery in VX2 tumor bearing rabbit models; TACE group: 5 mg adriamycin combine 0.5 mL iodized oil was perfused via hepatic artery in VX2 tumor bearing rabbit models. The tumor volume, necrosis area, ratio of necrosis area, number of intrahepatic and lung metastasis were examined 2 weeks after the different treatments. RESULTS: There is no significant difference in the tumor volume before the treatments (P ＞ 0.05). While after the different treatments, the tumor volume in experimental groups especially TACE group were suppressed obviously comparing with the control group(P ＜ 0.01), and larger necrosis in TACE groups was observed comparing with the control group and TAI groups (P ＜ 0.01); In the TACE group, there were more intrahepatic and lung metastasis comparing with the control group and TAI groups (P ＜ 0.05). CONCLUSION: TACE can inhibit transplanted VX2 liver tumor growth and induce tumor necrosis, but can also increase intrahepatic and lung metastasis of transplanted VX2 liver tumor.
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万方数据
维普
