经肝动脉化疗栓塞对兔肝VX2移植瘤生长与转移的影响
Effects of transcatheter arterial chemo-embolization on growth and metastasis of rabbit VX2 hepatic tumor
吕良山 1马清涌 2刘亚民3
作者信息
- 1. 西安交通大学医学院第一附属医院,消化内科,陕西,西安,710061
- 2. 西安交通大学医学院第一附属医院,肝胆外科,陕西,西安,710061
- 3. 西安交通大学医学院第一附属医院,周围血管科,陕西,西安,710061
- 折叠
摘要
目的:评价经肝动脉化疗栓塞(Transcatheter arterialchemoembolization,TACE)对兔肝VX2移植瘤生长与转移的影响.方法:45只荷瘤兔随机分成3组,每组15只.A组为对照组(Control组):经肝动脉灌注0.5 mL生理盐水;B组为化疗灌注(transcatheter hepatic arterial infusion,TAI)组(TAI组):经肝动脉灌注5 mg阿霉素与0.5 mL生理盐水的稀释液;C组为化疗栓塞组(TACE组):经肝动脉灌注5 mg阿霉素与0.5mL碘化油的混悬液.经股动脉穿刺插管,依分组情况行介入治疗.比较不同处理组术后2 wk肝移植瘤的增长率、坏死率以及肝内转移、肺转移的发生率.结果:介入治疗前各组肿瘤平均体积之间无显著性差异(P>0.05);与对照组及TAI组相比,介入治疗后TACE组肿瘤体积、肿瘤增长率明显降低(P<0.01),肿瘤的坏死率明显增加(P<0.05),肿瘤的肝内转移、肺转移的发生率明显增加(P<0.05).结论:TACE能够抑制兔肝VX2移植瘤的生长,但增加术后肝内转移和肺转移的发生率.
Abstract
AIM: To evaluate the efficency, as well as effects of transcatheter arterial chemoembolization (TACE) on growth and metastasis of rabbit VX2 hepatic tumor. METHODS: 45 rabbits with implanted hepatic VX2 tumor were randomly divided into 3 groups with 15 rabbits in each group. Control group: 0.5 mL saline was perfused via hepatic artery in VX2 tumor bearing rabbit models; Transcatheter hepatic arterial infusion (TAI) group: 5 mg adriamycin was perfused via hepatic artery in VX2 tumor bearing rabbit models; TACE group: 5 mg adriamycin combine 0.5 mL iodized oil was perfused via hepatic artery in VX2 tumor bearing rabbit models. The tumor volume, necrosis area, ratio of necrosis area, number of intrahepatic and lung metastasis were examined 2 weeks after the different treatments. RESULTS: There is no significant difference in the tumor volume before the treatments (P ＞ 0.05). While after the different treatments, the tumor volume in experimental groups especially TACE group were suppressed obviously comparing with the control group(P ＜ 0.01), and larger necrosis in TACE groups was observed comparing with the control group and TAI groups (P ＜ 0.01); In the TACE group, there were more intrahepatic and lung metastasis comparing with the control group and TAI groups (P ＜ 0.05). CONCLUSION: TACE can inhibit transplanted VX2 liver tumor growth and induce tumor necrosis, but can also increase intrahepatic and lung metastasis of transplanted VX2 liver tumor.
关键词
化疗栓塞/肝肿瘤/转移Key words
chemoembolization/liver cancer/metastasis引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据