鼻型NK/T细胞淋巴瘤增生活性的研究
A study on the proliferative activity of nasal NK/T-ceH lymphoma
王映梅 1范林妮 1胡沛臻 1何芙蓉 1朱瑾 1刘一雄 1王璐 1黄高昇1
作者信息
- 1. 第四军医大学西京医院病理科,陕西,西安,710033
- 折叠
摘要
目的:研究鼻型NK/T恶性淋巴瘤的增生活性.方法:应用免疫组织化学EnVision法研究31例鼻型NK/T细胞淋巴瘤和12例鼻咽黏膜反应性病变的增生活性,并统计分析Ki67标记指数(Ki67 LI).结果:免疫表型分析支持31例鼻型NK/T恶性淋巴瘤的诊断.31例NK/T细胞淋巴瘤的平均Ki67 LI为0.37±0.03,12例反应性病变为0.07±0.02,两组间有差异显著(P<0.01).若将31例NK/T细胞淋巴瘤按高于或低于平均Ki67 LI分为2组,则高于平均Ki67 LI者19例,占61%;低于平均Ki67LI者12例,占39%.将低于平均Ki67 LI的12例NK/T细胞淋巴瘤(0.2±0.02)与12例反应性病变相比(0.07±0.02)相比,也有统计学差异(P<0.001).结论:鼻型NK/T恶性淋巴瘤是一种增生活性异质性明显的恶性肿瘤.Ki67 LI有助于鼻型NK/T恶性淋巴瘤的诊断.
Abstract
AIM: To investigate the proliferative activity of nasal NK/T-cell lymphoma. METHODS: The proliferative activity of 31 cancer cases and 12 nasal reactive lesions was detected by Ki67 labeling index (Ki67 LI) and analyzed by statistic software. RESULTS: The diagnosis of nasal NK/T-cell lymphoma in all 31 cases was further confirmed by immunophenotypic analysis. Ki67 LI in 31 cases of the tumor was 0.37 ± 0.03 and in nasal reactive lesions was 0.07 ± 0.02. Statistically, there was a significant difference between the 2 groups (P ＜ 0.001). If 31 cases of the tumor were divided into the 2 groups, i. e. high and low proliferative ones, based on the mean value of Ki67 LI, 19 cases (61.3%) showed higher Ki67 LI and 12 cases (38.7%) showed lower Ki67 LI. Importantly, Ki67 LI in the low proliferative group was still significantly higher than that of nasal reactive lesions (P ＜ 0.001). CONCLUSION: Nasal NK/T-cell lymphoma was a kind of malignant tumor with obviously heterogeneous proliferation. Ki67 LI was useful in a pathological diagnosis of nasal NK/ T-cell lymphoma.
关键词
NK/T细胞淋巴瘤/Ki67标记指数/免疫组织化学Key words
NK/T cell lymphoma/Ki67 label index/immunohistochemistry引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据