A study on the proliferative activity of nasal NK/T-ceH lymphoma
AIM: To investigate the proliferative activity of nasal NK/T-cell lymphoma. METHODS: The proliferative activity of 31 cancer cases and 12 nasal reactive lesions was detected by Ki67 labeling index (Ki67 LI) and analyzed by statistic software. RESULTS: The diagnosis of nasal NK/T-cell lymphoma in all 31 cases was further confirmed by immunophenotypic analysis. Ki67 LI in 31 cases of the tumor was 0.37 ± 0.03 and in nasal reactive lesions was 0.07 ± 0.02. Statistically, there was a significant difference between the 2 groups (P ＜ 0.001). If 31 cases of the tumor were divided into the 2 groups, i. e. high and low proliferative ones, based on the mean value of Ki67 LI, 19 cases (61.3%) showed higher Ki67 LI and 12 cases (38.7%) showed lower Ki67 LI. Importantly, Ki67 LI in the low proliferative group was still significantly higher than that of nasal reactive lesions (P ＜ 0.001). CONCLUSION: Nasal NK/T-cell lymphoma was a kind of malignant tumor with obviously heterogeneous proliferation. Ki67 LI was useful in a pathological diagnosis of nasal NK/ T-cell lymphoma.
NETL
NSTL
万方数据
维普
