Association of CDH1 gene polymor-phisms with esophageal squamous cell carcinoma in Shaanxi Province
AIM: To explore the influence of the single nucleo-tide polymorphism (SNP) variants in CDH1 on the development and lymphatic metastases of esophageal squamous cell carcinoma (ESCC). METHODS: We conducted a population- based case control study in 218 patients with esophageal squamous cell carcinoma and 218 healthy controls. CDH1 genotypes were determined by PCR with restriction fragment length polymorphism (PCR - RFLP). RESULTS: The overall genotype and allelotype distribution of the CDH1 polymorphisms in ESCC patients were significantly different from those in healthy controls (P ＜ 0.05). Stratification analysis found that in either smoking group or non-smoking group the frequency of CDH1 allele in ESCC and healthy groups is significantly difference (P ＜ 0.05). The ESCC cases were further stratified according to the status of lymphatic metastasis at the time of diagnosis. No significant difference was observed in the frequencies of the CDH1 genotypes between ESCC patients with positive and negative lymphnode (P ＞ 0.05). CONCLUSION: The C-160A of CDH1 polymorphism is associated with the incidence of esophageal squamous cell carcinoma in the Shaanxi Province, but not associated with the lymphatic metastasis and prognosis of ESCC.
ESCCpolymorphism, single nucleotide polymorphismdisease susceptibility
NETL
NSTL
万方数据
维普
