目的:了解中国人群中16个原发性高血压(Essen-tial hypertension,EHT)候选基因的基因型和单体型分布情况及与EHT的关系.方法:采用基因芯片技术和Phase v 2.1单体型分析软件,检测和分析140例EHT患者和400例健康对照者16个心血管疾病易感基因的基因型和单体型.结果:EHT组和健康对照组间的AGT235,ApoBXall和ACEAlu等位基因频率差异显著(P<0.05),且ACEAlu在不同等级的高血压中的分布亦具有显著差异(P<0.05).人群中共有918种单体型,单体型MIEG+-C3CC在两组间分布差异分析,P=0.052.结论:AGT235M,ACAluD和ApoBXall+可能与中国汉族人群原发性高血压有关.
Case-control study of 16 cardiovascular Disease's predisposing gene SNPs in Chinese Han population
AIM: To investigate the distribution of 16 (essential hypertension) EHT candidate genotypes and haplotypes and to analyze their association with essential hypertension. METHODS: The genotypes and hapotypes in 140 EHT patients and 400 healthy controls in Han population were analyzed with gene array technology and haplotye analysis software PHASE V 2.1. RESULTS: Significant differences were found in AGT235 M/T, ApoBXalⅠ and ACEAlu I/D allele gene frequencies between EHT patients and healthy control (P ＜ 0.05). Whether the frequency of MIEG + -C3CC in EHT patients was statistically different from that in healthy controls (P = 0.052) needed further research. CONCLUSION: AGT235 M, ApoBXal Ⅰ + and ACEAlu D mainly contribute to the onset and progression of EHT in Han population.
polymorphism, single nucleotideoligonucleotide array sequence analysisessential hypertension
NETL
NSTL
万方数据
维普
