甲状腺内胎儿微嵌合体在产后Graves病发病的影响
Influence of the microchemirism in the thyroid glangs to post-partum Graves' disease
蒲丹 1郭辉 1何岚 1马爱群1
作者信息
- 1. 西安交通大学医学院第一附属医院,陕西,西安,710061
- 折叠
摘要
目的:探讨甲状腺内胎儿微嵌合体对女性产后Graves病发病的影响.方法:选用Y染色体α卫星区特异性DNA探针,利用荧光原位杂交技术,检测24例GD和10例甲状腺腺瘤患者甲状腺石蜡标本中的胎儿嵌合体的存在.结果:24例产后GD患者甲状腺标本中13例发现存在着Y染色体,10例甲状腺腺瘤对照组中仅2例存在有Y染色体.两组间胎儿微嵌合体的出现率存在显著性差异(54.2% us20%,P<0.05).比较GD患者中胎儿嵌合体阳性和阴性病例的的临床资料,显示胎儿嵌合体阳性组患者的妊娠次数(平均2.77 ±0.38次)显著多于胎儿微嵌合体阴性组(平均1.36±0.27次)(P<0.05).结论:胎儿微嵌合体在GD患者甲状腺内出现的机率的确较非AITD的患者更高,提示胎儿微嵌合体可能参与产后GD的发生.
Abstract
AIM: To explain the influence of the fetal microchemirism in the thyroid tissue to post-partum Graves' disease (GD). METHODS:Twenty-four GD thyroid tissue samples and 10 adenoma thyroid tissue samples were collected from the first hospital of Xi'an Jiaotong University. Using the Y chromosome special α-satellite-region probes, the Y chromosome in the female patients' thyroid tissue was test by fluorescence insitu hybridization (FISH). RESULTS: The difference in the appearance ratio of male cells between Graves' disease and adenoma was statistically significant (54.2% vs 20%, P ＜ 0.05). Compared the clinical history of the patients, we found the pregnancy times of male-cells-positive GD patients was more than that of male-cells-negative GD patients (2.77 ± 0.38 vs 1.36 ± 0.27, P ＜ 0.05). CONCLUSION: Inrrathyroidal fetal microchimerism are probably involved in the pathogenesis of post-partum GD. And the pregnancy times was the major role that influent the present of the fetal microchimerism.
关键词
Graves病/胎儿微嵌合体/产后Key words
Graves disease/microchimerism/post-partum引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据