Influence of the microchemirism in the thyroid glangs to post-partum Graves' disease
AIM: To explain the influence of the fetal microchemirism in the thyroid tissue to post-partum Graves' disease (GD). METHODS:Twenty-four GD thyroid tissue samples and 10 adenoma thyroid tissue samples were collected from the first hospital of Xi'an Jiaotong University. Using the Y chromosome special α-satellite-region probes, the Y chromosome in the female patients' thyroid tissue was test by fluorescence insitu hybridization (FISH). RESULTS: The difference in the appearance ratio of male cells between Graves' disease and adenoma was statistically significant (54.2% vs 20%, P ＜ 0.05). Compared the clinical history of the patients, we found the pregnancy times of male-cells-positive GD patients was more than that of male-cells-negative GD patients (2.77 ± 0.38 vs 1.36 ± 0.27, P ＜ 0.05). CONCLUSION: Inrrathyroidal fetal microchimerism are probably involved in the pathogenesis of post-partum GD. And the pregnancy times was the major role that influent the present of the fetal microchimerism.
NETL
NSTL
万方数据
维普
