甘肃省裕固族人群ACAT2基因多态性与原发性高血压及血脂水平的关系
Relationship between the polymor-phism of ACAT2 gene with essential hypertension and blood lipids in Yugu minority of Gansu Province
马慧元 1马丽雅 2王楠 2巴战生 3李兴祥4
作者信息
- 1. 兰州大学第一临床医学院,甘肃,兰州,730000;甘肃省人民医院干三科,甘肃,兰州,730000
- 2. 甘肃省人民医院干三科,甘肃,兰州,730000
- 3. 肃南裕固族自治县人民医院,内科,甘肃,肃南,734400
- 4. 肃南裕固族自治县人民医院,检验科,甘肃,肃南,734400
- 折叠
摘要
目的:探讨甘肃省裕固族人群酰基辅酶A:胆固醇酰基转移酶2(ACAT2)基因734C/T多态性与原发性高血压(EH)及血脂水平的关系.方法:裕同族原发性高血压患者102例,对照组112例,应用聚合酶链反应.限制性片段长度多态性(PCR-RELP)技术分析ACAT2基因第7外显子734C/T多态性,同时测定血脂水平.结果:ACAT2基因734C/T各基因型频率分布在高血压组与对照组之间的差异无统计学意义(X2=4.544,P=0.103),而高血压组T等位基因频率分布低于对照组,差异具有统计学意义(X2=4.025,P=0.045).高血压组各基因型之间血脂水平差异均无统计学意义(P>0.05).结论:734 T等位基因可能具有减少裕固族原发性高血压病发生的作用.ACAT2-734C/T基因多态性与裕固族高血压患者空腹血脂水平无明显相关性.
Abstract
AIM: To investigate the relationship between the 734C/T polymorphism of acyl-coenzyme A: cholesterol acyltransferase2 (ACAT2) gene with essential hypertension (EH) and blood lipids in Yugu minority of Gansu Province. METHODS: Polymerase chain reaction restriction fragment length polymorphisms (PCR-RELP) technique was used to analyze the 734C/T polymorphism. The blood lipids were also measured. The study covered 102 hypertensives and 112 controls of Yugu minority. RESULTS: The distribution of genotype frequencies of ACAT2 gene 734C/T polymorphism in hypertensives was similar to that in controls (χ2 = 4.544, P = 0.103). The T allele of 734C/T was significantly lower in hypertensives (χ2 = 4.025, P = 0.045). However, the level of blood lipids of ACAT2 genotype in hypertensives was no significant difference (P ＞ 0.05). CONCLUSION: The T allele of 734C/T may be protective against essential hypertension in Yugu minority. The ACAT2 gene 734C/T polymorphism was not affect the level of fasting blood lipid in hypertensives of Yugu minority.
关键词
原发性高血压/ACAT2/基因多态性/血脂/裕固族Key words
essential hypertension/ACAT2/genetic polymorphism/blood lipid/Yugu minority引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据