睡眠剥夺后静息状态下前扣带回功能连接模式的改变
Changes of functional connectivity of ACC in resting state during slee pdeprivation: An fMRI study
叶恩茂 1邵永聪 2毕国华 3马林 4杨征 3陈武凡5
作者信息
- 1. 南方医科大学生物医学工程学院,广东,广州,510515;军事医学科学院基础医学研究所,北京,100850
- 2. 军事医学科学院基础医学研究所,北京,100850;第四军医大学航空航天医学系心理学教研室,陕西,西安,710033
- 3. 军事医学科学院基础医学研究所,北京,100850
- 4. 解放军总医院,北京,100853
- 5. 南方医科大学生物医学工程学院,广东,广州,510515
- 折叠
摘要
目的:探讨睡眠剥夺对静息态脑功能连接模式的影响.方法:对14名健康男性大学生进行两次静息态功能磁共振成像扫描.第1次扫描在正常睡眠清醒后12 h完成,第2次扫描于睡眠剥夺36 h后完成.选取前扣带回为种子区域进行静息态脑功能连接分析.结果:睡眠剥夺后与前扣带回的功能连接增强的脑区有顶叶皮层、岛叶、颞叶等,下降的脑区有丘脑.结论:清醒状态的维持主要由丘脑等皮层下区域负责,机体的默认网络系统在睡眠剥夺后功能连接增强,反映了默认网络系统功能的一致变化,这与机体的注意、抑制功能的下降及清醒状态的下降相关.
Abstract
AIM: To explore the impact of total sleep deprivation (TSD) on functional connectivity of ACC in resting state. METHODS: Healthy young men (n = 14) completed rest fMRI scan before and after the 36-TSD. fMRI scans were carried out in these subjects 3 weeks apart. RESULTS: TSD induced positive and negative functional connectivity compared with that after the normal sleep. The activated areas with positive FC include the PC, etc. and with negative FC in thalamus. CONCLUSION: The maintaining of awareness is supported by thalamus during rest state. The strengthening functional connectivity of default network in sleep deprivation reflects the consistent changes in the system, which may be related to the impacting function of attention and inhibition system and the decline of wakefulness.
关键词
睡眠剥夺/功能磁共振成像/前扣带回/功能连接/默认网络Key words
total sleep deprivation/functional magnetic resonance imaging/anterior cingulated cortex/functional connectivity引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据