Effects of fructose sodium diphosphate on the plasma brain natriuretic peptide levels in children with acute leukemia treated by daunorubicin
AIM: To explore the value of brain natriuretic peptide (BNP) in diagnosing the myocardiopathy induced by daunorubicin (DNR) and the more effective cardiac-protection drugs by investigating the changes of the BNP levels after adminis trating DNR in children with acute leukemia. METHODS: Thirty-one children with acute leukemia treated with a daunorubicin (DNR)-containing regimen were randomly divide into 2 groups. Experimental group received FDP as the cardiac-protection drug and Shenmai injection was used in control group during chemotherapy with DNR. Plasma BNP concentrations was measured by enzyme linked immunosorbent assay (ELISA) and ECG and cardiac muscle enzyme (LDH1, CPK-MB) were performed before and after administrating DNR routinly. RESULTS: The plasma BNP concentrations increased from (3.89 ± 1.43) ng/L to(15.12 ± 4.38) ng/L (P ＜ 0.001) in experiment group and increased from (3.72 ± 1.38)ng/L to(18.45 ± 5.29)ng/L(P ＜ 0.001)in control group after treated with DNR. There was no significant difference between two groups before chemotherapy(P ＞ 0.05) and a significant difference after chemotherapy (P ＜ 0.001). The plasma BNP concentrations was lower in experiment group than in control group (P ＜ 0.001). However, ECG and cardiac muscle enzymes(LDH1, CPK-MB) had no significant difference in all children with acute leukemia. CONCLUSION: BNP can be served as a good indicator for DNR-induced myocardiopathy and maybe FDP is more effective than shenmai in protecting heart during chemotherapy with DNR.
NETL
NSTL
万方数据
维普
