首页|内皮素-1反义脱氧寡核苷酸对糖尿病肾病大鼠肾组织形态学的影响

内皮素-1反义脱氧寡核苷酸对糖尿病肾病大鼠肾组织形态学的影响

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目的:研究内皮素-1反义脱氧寡核苷酸(ET-1ASODN)对链脲佐菌素(streptozotoein,STZ)诱导的糖尿病大鼠肾组织形态学的保护作用及其机制.方法:一次性腹腔注射STZ(60 mg/kg),建立大鼠糖尿病模型,观察ET-1AS-ODN预防性给药对大鼠肾组织形态结构的保护作用.结果:ET-1ASODN可明显减轻精尿病大鼠肾肥大指数,改善肾组织形态学损伤.结论:内皮素-1反义寡核苷酸可减轻STZ诱导的糖尿病肾病大鼠的肾损伤,对肾组织具有保护作用.其机制与减少内源性内皮素的产生有关.
Protective effects of endothelin-1 mRNA antisense oligodeoxynucleotide on the kidney ultrustructure of streptozotocin-induced diabetic nephropathy rats
AIM: To investigate the protective effects of endothelin-1 mRNA antisense oligodeoxynucleotide (ET-1 AS-ODN) on the renal morphology of diabetic nephropathy(DN) and discuss the pathogenesis and mechanism of DN in a diabetic rat model. METHODS: Diabetic rats were induced by intraperitoneal administration of streptozotocin (STZ) at 60 mg/kg. ET-1 AS-ODN was administrated intravenously to the treatment groups and its protective effects on renal morphology were observed. RESULTS: Compared with the DM group, the kidney index reduced significantly the general condition and morphological injury improved significantly in ET-1 AS-ODN treatment groups. CONCLUSION: Endothelin-1 mRNA antisense oligodeoxynucleotide has a protective effect on the kidney by preventing renal impairment in diabetic nephropathy rats. The mechanism of the protective effect of Endothelin-1 mRNA antisense oligodeoxynucleotide involves inhibition of endogenous ET-1 production.

endothelin-1 mRNA antisense oligodeoxynucleotidediabetic nephropathymorphologyendothelin

余建强、李玉香、王洁、张焱、王淑静、袁文俊

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宁夏医科大学,基础医学院药理学系,宁夏,银川,750004

宁夏医科大学,护理学院基础护理学系,宁夏,银川,750004

宁夏医科大学,科技中心,宁夏,银川,750004

宁夏医科大学,基础医学院生理学系,宁夏,银川,750004

第二军医大学生理学教研室,上海,200003

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内皮素-1反义寡核苷酸 糖尿病肾病 形态学 内皮素

宁夏高等学校科学技术研究项目宁夏高等学校科学技术研究项目宁夏卫生厅重点科研计划宁夏医科大学科学技术研究项目

宁教高[2007]292号-103宁教高[2007]292-87W2008087XM200832

2009

第四军医大学学报
第四军医大学

第四军医大学学报

CSTPCDCSCD北大核心
影响因子：0.599
ISSN：1000-2790
年,卷(期)：2009.30(20)
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