Protective immunity of recombinant EgP-29 against Echinococcus Granulosus in mice
AIM: To investigate the protective immunity against Echinococcus granulosus in mice immunized with rEgP-29 and its potential as vaccine candidate. METHODS: ICR mice were subcutaneously immunized three times with rEgP-29 and then challenged with Echinococcus granulosus. The rate of reduced hydatid cyst and the levels of IgE, IgG and IgG subclasses in sera were examined, with adjuvant group as control. RESULTS: The rate of reduced hydatid cyst in rEgP-29 group was 96.6%. The levels of IgG, IgG1, IgG2a and IgE increased obviously, that of IgG2b decreased remarkably. CONCLUSION: The rEgP-29 antigen could induce partial protection against Echinococcus granulosus. These data demonstrate the potential of rEgP-29 as a Echinococcus granulosus vaccine candidate.
NETL
NSTL
万方数据
维普
