Effects of atorvastatin on the pathological changes of brain tissue and the level of MMP-9 in plasma in rats with intracerebral hemorrhage
AIM: To explore the effects of various doses of atorvastatin on the edema of brain tissue, the apoptosis of neurocytes and the level of matrix metalloproteinase-9 (MMP-9) in plasma after intracerebral hemorrhage (ICH) in rats. METHODS: Making models with ICH by injecting collagenase into rats' putamen. The brain water content was determined with the wet and dry weight method, the ultrastructural changes of brain tissue were observed by electronmicro-scopy, the level of MMP-9 in plasma was determined with ELISA. RESULTS: Atorvastatin showed significant effect in reducing the brain water content, blocking the apoptosis of neurones of the ICH rats and decreasing the level of MMP-9 in plasma. There was a positive linear correlation between the level of MMP-9 in plasma and the brain water content. CONCLUSION: Atorvastatin can obviously relieve the brain edema, decrease the brain injury caused by MMP-9 and protect neurons of the ICH rats.
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万方数据
维普
