Study of voltage-sensitive-dye in experimental epileptic animal model
AIM: To judge the area of the cortical epileptic focus accurately, dyeing with voltage-sensitive-dye. METHODS: The experimental group, to establish the acute epileptic model of New Zealand rabbit, were injected the Penicillin in the cerebral cortex. The control group were injected the Saline in the cerebral cortex. Dyed with voltage-sensitive-dye, observed and noted the colour changing. RESULTS: Dyed with voltage-sensitive-dye, observed for 30 min, the cerebral cortex were dyed to red. In the control group we saw the color of the cerebral cortex put up red all along and didn't appear any abnormal color. But in the experiment group, whose color showed the change. The pigmentation rate of the epileptic focus was 89.47%. CONCLUSION: The cerebral cortical epileptic focus may be dyed by voltage-sensitive-dye in the live animal model, which can confirm the area accurately.
voltage-sensitive-dyedyeingpenicillinepileptic model
NETL
NSTL
万方数据
维普
