Influence of tumor necrosis factor-α on erythropoietin production in patients with malignant hematological diseases
AIM: To explore the influence of tumor necrosis factor-α on erythropoietin production in patients with hematologic malignancies. METHODS: Fifty-three hematologic malignancy patients with anemia and 21 hematologic malignancy patients with non-anemic were studied. Serum EPO levels were measured by radioimmunoassay(RIA) and serum soluble transferrin receptor (sTfR), TNF-α levels by enzyme-linked immunosorbent assay (ELBA). Log transformed EPO and sTfR values were used in statistical analysis. The R correlation analyses were performed. RESULTS: The mean serum immunoreactive erythropoietin level in hematologic malignancy patients with anemia was significandy lower than in IDA patients with similar degree of anemia and O/P sTfR were significantly lower in hematologic malignancy patients with anemia than in controls and in hematologic malignancy patients with non-anemic. There was no significant diference between the latter 2 groups. Furthermore, the expected inverse linear relation between serum EPO and hemoglobin levels was absent in the hematologic malignancy patients with anemia, and so did the relation between serum sTfR and hemoglobin levels. There was no corelation between O/P EPO and O/P TfR. The serum levels of TNF-α were signifieanfly higher than those in healthy controls or in hematologic malignancy patients with non-anemic. The serum levels of TNF-α were inversely correlated with hemoglobin levels(r = -0.22, P = 0.13),O/P EPO(r = -0.35,P = 0.01)or O/P sTfR(r = -0.39,P = 0.006). CONCLUSION: Anemia of cancer is due to impaired erythropoiesis and relative inadequacy of EPO production. TNF-α might inhibit EPO production and erythropoiesis.
NETL
NSTL
万方数据
维普
