Relationship between MR manifestion of lymph nodes metastasis of napharyngeal carcinoma and P53 expression
AIM: To study the relationship between MR imaging manifestations of lymph nodes metastasis of naspharyngeal carcinoma(NPC) and expression of p53 protein. METHODS: One hundred and ten patients, who had been diagnosed with NPC and whose MR imaging was performed before treatment, were enrolled in this study. The expression of p53 protein was detected by S-P immunohistochemical technique and a comparison was made between the MM manifestations of the lymph nodes metastasis of the napharyngeal carcinoma and p53 expression. RESULTS: The bilateral metastasis rate of cervical nodes was 34.0% (17/50) and the bilateral metastasis rate of the retropharyngeal lymph nodes was 11.4% (4/34), with statistically significant difference (χ2 = 5.64, P = 0.018). The cervical nodes metastasis rate in patients with and without prestyloid space involvement was respectively 48.4% (30/62) and 52.1% (25/48), with no statistically significant difference (χ2 = 0.148, P = 0.701). The cervical nodes metastasis rate in patients with and without retrostyloid spaces involvement was respectively 68.2% (30/44) and 30.3% (20/66), with statistically significant difference (χ2 = 15.278, P = 0.000). The positive-expression rate of p53 proteins was 78.0% (39/50) in patients with cervical nodes metastasis and 77.1% (27/35) in patients with retropharyngeal lymph nodes metastasis, with no statistically significant difference (χ2 = 0.028, P = 0.868 and χ2 = 0.000, P = 0.982). CONCLUSION: The lymph nodes metastasis rate is high in naspharyngeal carcinoma. Cervical nodes metastasis is highly correlated to the retrostyloid spaces involvement, but lymph nodes metastasis is not correlated to the expression of p53 protein.
NETL
NSTL
万方数据
维普
