早期应用国产辛伐他汀对急性冠脉综合征患者C-反应蛋白、FDP及D-二聚体的影响
Effect of early different-dose simvastatin therapy on the serum C-reactive protein, fibrin degradation product and D-dimer in the patients with acute coronary syndrome
叶毅敏 1叶志荣2
作者信息
- 1. 泉州医学高等专科学校临床医学系内科教研室,福建,泉州,362000
- 2. 泉州市第一医院四区心内科,福建,泉州,362000
- 折叠
摘要
目的:探讨急性冠脉综合征(ACS)患者住院早期(24～48 h)应用不同剂量国产辛伐他汀后血清C反应蛋白(CRP)、FDP及D-二聚体影响以及血脂的变化及其临床意义.方法:连续入选ACS 90例患者,随机分为3组:辛伐他汀20 mg组30例、10 mg组30例、对照组30例.他汀类两组均于入院24～48 h内给予辛伐他汀治疗.测定三组人院时、入院后8 wk高敏C反应蛋白(hs-CRP)、FDP及D-二聚体和血脂的变化.结果:ACS患者住院早期应用辛伐他汀不仅可以降低血脂水平,而且可明显降低hs-CRP,FDP及D-二聚体水平,且20 mg作用优于10 mg.这种益处在治疗8 wk后即可见.结论:早期应用辛伐他汀可明显降低ACS患者的炎症及凝血反应,20 mg作用明显优于10 mg.
Abstract
AIM: To evaluate the effect of early different-dose simvastatin therapy on the serum C-reactive protein (CRP), fibrin degradation product (FDP) and D-dimer in the patients with acute coronary syndrome (ACS), except the change of the blood-lipid. METHODS: Ninety patients with ACS were divided into 3 groups. The patients in group 1 (n = 30) received simvastatin (20 mg/d). The patients in group 2(n = 30) received simvastatin (10 mg/d) and the group 3 was the control group (n = 30). The patients in group 1 and in group 2 were treated with simvastatin within 24-48 h after hospitalization. The levels of the high sensitivity CRP(hs-CRP), FDP, D-dimer and the blood-lipid were measured at baseline and after 8 weeks of therapy. RESULTS: After 8 weeks of therapy, early different-dose simvastatin treatmemt can not only decrease the serum level of blood-lipid, but also decrease the serum level of hs-CRP, FDP and D-dimer. The higher dose, the more effect. CONCLUSION: Early simvastatin treatmemt can inhibit inflammtion and blood coagulative reation obviously. As the dose is higher,the effect is more obvious.
关键词
辛伐他汀/急性冠脉综合征/C反应蛋白/FDP/D-二聚体Key words
simvastatin/acute coronary syndrome/C reactive protein/fibrin degradation product/D-dimer引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据