Clinical evaluation of the safty and feasibility of mico-flow closed-circuit anesthesia performing in one-lung ventilationation
AIM: To evaluate the feasibility of micro-flow closed-circuit anesthesia (MFCCA) in patients undergoing one-lung ventilation(OLV) during elective thoracic surgery, and to provide the consequent safe parameters. METHODS: Thirty patients, scheduled for thoracic surgery were allocated into the study. The patients were divided into MFCCA group (group Ⅰ, n = 15 and SCA group ( group Ⅱ, n = 15) When the operation began, hemodynamic (HR, SBP, DBP, MAP) and multi-gas parameters(FiO2 and FeO2, Fet CO2 and FinCO2, FinISO and FexISO) were recorded at following intervals:①TLV before changing OLV(T1), ② 15, 30, 60 min during the course of OLV(T2, T3, T4), ③ OLV before changing TLV(T5). The arterial/venous blood samples were taken at the above intervals for blood gas analysis simultaneously. RESULTS: FiO2 and FeO2 during OLV in group Ⅰ were significantly lower than during TLV in lateral position(P ＜ 0.05). The Isoflurane concentration (FinISO and FexISO) in group Ⅰ during TLV and OLV was significantly higher than in group Ⅱ (P ＜0.05), the FinISO and FexISO were stable duing the OLV intervals (T2, T3, T4, T5) in group Ⅰ, the group Ⅱ needed more time to reach the stable concentration, and needed large Isoflurane dosage to reach the predetermined concentration of group Ⅰ. The OLV increased PaO2 decreased significantly(P ＜ 0.05) in the 2 groups. CONCLUSION: CA performing in patients undergoing OLV during elective thoracic surgery is feasible, and the depth of anesthesia was satisfied. The FiO2 were all above 80%. The safe duration of OLV under MFCCA with Isoflurane was 1.5 h.
NETL
NSTL
万方数据
维普
