Effect of enriched environment on emotional behaviour in senescence accelerated-prone mice 8
AIM: To explore the effect of enriched environment on emotional behaviour in senescence accelerated-prone mice 8 (SAMP8). METHODS: Three-month female SAMP8 and 3-month female senescence accelerated-resistant mice1 (SAMR1) were divided into Enriched Environment (EE) group (n = 16) and Standard Environment (SE) group (n = 10) by random. After 3 months, the emotional behaviour was tested by Elevated Plus-Maze(EPM) and brain derived neurotrophic factor(BDNF) mRNA expression in hippocampus was tested by RT-PCR. RESULTS: EE mice had higher open arm entry percentage (OE%) and open arm time percentage(OT%) compared with SE mice (P ＜ 0.01). EE mice had higher BDNF mRNA expression in hippocampus compared with SE mice (P ＜ 0.01). CONCLUSION: EE could improve BDNF mRNA expression in hippocampus of SAMP8. EE also could change the emotional behaviour, which showed that EE could reduce the anxiety behaviour of SAMP8.
NETL
NSTL
万方数据
维普
