Study on whether the executive control functions of frontal cortex were influenced by 43 h total sleep deprivation by event-related potentials
AIM: To verify the hypothesis that executive control functions were impaired by 43 h total sleep deprivation by event-related potentials. METHODS: A visual Go/Nogo task was administrated to 12 total sleep-deprived subjects at 2:00 AM on day 3 (after 43 h total sleep deprivation) and to 12 non-sleep-deprived subjects at the same time[age(19 ± 1.6) years, male]. Electroencephalogram was recorded from 32 electrodes during the performed Go/Nogo task. RERULTS: The amplitudes of the P2 [F(1, 22) = 3.84, P ＜ 0.05], N2[F(1, 22) = 5.00, P ＜ 0.05] and P3[F(1, 22) =36.49, P ＜ 0.01] became higher for the than for the total sleep-deprived group than that for the control group. Their latencies also obviously prolonged after 43 h total sleep deprivation (N1:F (1, 22) = 99.54, P ＜ 0.01, P2: [F(1, 22) = 64.91, P ＜ 0.01], N2:[F(1, 22) =58.05, P＜ 0.01, P3: F(1, 22) =16.02, P＜0.01]. Besides, the amplitude of the N2 was obviously larger on the Nogo trials compared to the Go trials in the visual Go/Nogo task. Behavior data found that the mean correct reaction time [F(1, 22) = 9.99, P ＜ 0.05], misses [F(1, 22) = 22.15, P ＜ 0.01] and false alarm rate [F (1, 22) = 30.07, P ＜ 0.01] significantly increased for the total sleep-deprived group. CONCLUSION: These suggest that executive control functions were remarkably attenuated after 43 h of total sleep deprivation.
total sleep deprivationexecutive control functionsevent-related potentials
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